TIGAR Antibody

Catalog Number:

43101

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9NQ88
Gene ID: 57103

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human TIGAR

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TIGAR protein.

Applications:

IHC

Background:

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF