PRPF19 Antibody

Catalog Number:

43084

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UMS4
Gene ID: 27339

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human PRPF19

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PRPF19 protein.

Applications:

WB IHC

Background:

Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234).?

References:

appl_detail:

Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:10-1:50

Datasheet PDF