NELFA Antibody

Catalog Number:

43591

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9H3P2
NCBI Gene ID: 7469

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human NELFA

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total NELFA protein.

Applications:

IHC WB

Background:

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

References:

appl_detail:

Western blotting: 1:200-1000
Immunohistochemistry: 1: 20-100

Datasheet PDF