ZCCHC9 Antibody

Catalog Number:

42879

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8N567
Gene ID: 84240

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human ZCCHC9

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ZCCHC9 protein.

Applications:

IHC

Background:

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZCCHC9 (zinc finger, CCHC domain containing 9) is a 271 amino acid protein that contains four CCHC-type zinc finger, suggesting a role in transcriptional regulation. The gene encoding ZCCHC9 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF