RASSF1 Antibody

Catalog Number:

42729

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9NS23
Gene ID: 11186

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human RASSF1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RASSF1 protein.

Applications:

IHC

Background:

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.?

References:

appl_detail:

Immunohistochemistry: 1:10-1:50

Datasheet PDF