EGLN1 Antibody

Catalog Number:

42722

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9GZT9
Gene ID: 54583

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human EGLN1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total EGLN1 protein.

Applications:

IHC

Background:

The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex.

References:

appl_detail:

Immunohistochemistry: 1:20-1:100

Datasheet PDF