GLRX2 Polyclonal Antibody

Catalog Number:

42684

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9NS18

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Glutaredoxin-2, mitochondrial protein (1-124aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total GLRX2 polyclonal antibody.

Applications:

IHC

Background:

Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

References:

[1]"Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria."Johansson C., Kavanagh K.L., Gileadi O., Oppermann U.J. Biol. Chem. 282:3077-3082(2007). [2]"Solution

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF