CNOT8 Polyclonal Antibody

Catalog Number:

42682

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UFF9

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human CCR4-NOT transcription complex subunit 8 protein (1-292aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total CNOT8 polyclonal antibody.

Applications:

IHC

Background:

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

References:

[1]The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex." Doidge R., Mittal S., Aslam A., Winkler G.S. PLoS ONE 7:E51331-E51331(2012). [2]Initial characterizat

appl_detail:

Immunohistochemistry: 1:20 - 1:200

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