Peptidyl-tRNA hydrolase ICT1, mitochondrial Polyclonal Antibody

Catalog Number:

42645

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q14197

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Peptidyl-tRNA hydrolase ICT1, mitochondrial protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Peptidyl-tRNA hydrolase ICT1, mitochondrial polyclonal antibody.

Applications:

WB

Background:

Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

References:

[1]"Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome."Koc E.C., Cimen H., Kumcuoglu B., Abu N., Akpinar G., Haque M.E., Spremulli L.L., Koc H.Front. Physiol. 4:183-183(2013). [2]"In

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF