Phosphoprotein Polyclonal Antibody

Catalog Number:

42627

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P69480

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant Rabies virus Phosphoprotein protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Phosphoprotein polyclonal antibody.

Applications:

WB

Background:

Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body

References:

[1]Nucleotide and deduced amino acid sequences of the nominal nonstructural phosphoprotein of the ERA, PM and CVS-11 strains of rabies virus.Larson J.K., Wunner W.H.Nucleic Acids Res. 18:7172-7172(1990)

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF