Titin Polyclonal Antibody

Catalog Number:

42592

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8WZ42

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Titin protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Titin polyclonal antibody.

Applications:

IHC

Background:

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

References:

[1] "Titins, giant proteins in charge of muscle ultrastructure and elasticity."Labeit S., Kolmerer B.Science 270:293-296(1995) [2] "Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibri

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF