Interleukin-29 Polyclonal Antibody

Catalog Number:

42566

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8IU54

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Interleukin-29 protein£¨21-200AA£©

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Interleukin-29 polyclonal antibody.

Applications:

IHC

Background:

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

References:

[1]"Construction of mammalian cell expression vector of human interleukin (IL)-28A, IL-28B and IL-29 gene from activated peripheral blood mononuclear cell and analysis of its sequence." Li M., He S. Submitted (JUL-2003). [2]"The DNA sequence and biology o

appl_detail:

Immunohistochemistry: 1:20 - 1:200

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