Phosphatidylcholine-sterol acyltransferase Polyclonal Antibody

Catalog Number:

42536

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P04180

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Phosphatidylcholine-sterol acyltransferase protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Phosphatidylcholine-sterol acyltransferase polyclonal antibody.

Applications:

WB IHC

Background:

Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms.

References:

[1]Human lecithin-cholesterol acyltransferase gene: complete gene sequence and sites of expression.McLean J., Wion K., Drayna D., Fielding C., Lawn R.Nucleic Acids Res. 14:9397-9406(1986) [2] Cloning and expression of human lecithin-cholesterol acyltrans

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF