Transferrin receptor protein 1 Polyclonal Antibody

Catalog Number:

42479

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P02786

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Transferrin receptor protein 1 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Transferrin receptor protein 1 polyclonal antibody.

Applications:

WB

Background:

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

References:

[1]"Primary structure of human transferrin receptor deduced from the mRNA sequence."Schneider C., Owen M.J., Banville D., Williams J.G.Nature 311:675-678(1984) [2] "The human transferrin receptor gene: genomic organization, and the co

appl_detail:

Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF