C-C motif chemokine 5 Polyclonal Antibody

Catalog Number:

42445

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P13501

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human C-C motif chemokine 5 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total C-C motif chemokine 5 polyclonal antibody.

Applications:

WB

Background:

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.

References:

[1] "A human T cell-specific molecule is a member of a new gene family."Schall T.J., Jongstra J., Dyer B.J., Jorgensen J., Clayberger C., Davis M.M., Krensky A.M.J. Immunol. 141:1018-1025(1988) [2] "Organization of the chemokine gene cluster on human ch

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF