Angiopoietin-2 Polyclonal Antibody

Catalog Number:

42440

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O15123

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Angiopoietin-2 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Angiopoietin-2 polyclonal antibody.

Applications:

IHC

Background:

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

References:

[1] "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis."Maisonpierre P.C., Suri C., Jones P.F., Bartunkova S., Wiegand S.J., Radziejewski C., Compton D.L., McClain J., Aldrich T.H., Papadopoulos N., Daly T.J., Davis S., Sato

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF