Transcription intermediary factor 1-beta Polyclonal Antibody

Catalog Number:

42428

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q13263

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Transcription intermediary factor 1-beta protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Transcription intermediary factor 1-beta polyclonal antibody.

Applications:

WB IHC

Background:

Forms a complex with a KRAB-domain transcription factor and increases the efficiency of KRAB-mediated repression. Silences transcription through an interaction with HP1 proteins. Acts as a corepressor of transcription for the KRAB zinc finger proteins and as a moderator of the repression activity. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of the Alpha-1-acid glycoprotein gene.

References:

[1] "KAP-1, a novel corepressor for the highly conserved KRAB repression domain."Friedman J.R., Fredericks W.J., Jensen D.E., Speicher D.W., Huang X.-P., Neilson E.G., Rauscher F.J. IIIGenes Dev. 10:2067-2078(1996) [2] "Transcriptional repression by RI

appl_detail:

Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF