Methylated-DNA--protein-cysteine methyltransferase Polyclonal Antibody

Catalog Number:

42551

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P16455

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Methylated-DNA--protein-cysteine methyltransferase

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Methylated-DNA--protein-cysteine methyltransferase polyclonal antibody.

Applications:

IHC

Background:

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

References:

[1] "Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine."Tano K., Shiota S., Collier J., Foote R.S., Mitra S.Proc. Natl. Acad. Sci. U.S.A. 87:686-690(1990) [2] "cDNA clo

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF