G-protein coupled receptor 161 Polyclonal Antibody

Catalog Number:

42408

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8N6U8

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human G-protein coupled receptor 161 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total G-protein coupled receptor 161 polyclonal antibody.

Applications:

WB

Background:

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

References:

[1]"Identification of a novel G-protein coupled receptor expressed in distinct brain regions and a defined olfactory zone."Raming K., Konzelmann S., Breer H.Recept. Channels 6:141-151(1998) [2] "Complete sequencing and characterization of 21,243 full-l

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF