Negative elongation factor B Polyclonal Antibody

Catalog Number:

42401

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8WX92

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Negative elongation factor B protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Negative elongation factor B polyclonal antibody.

Applications:

WB

Background:

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding.

References:

[1] "BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations."Ye Q., Hu Y.-F., Zhong H., Nye A.C., Belmont A.S., Li R.J. Cell Biol. 155:911-921(2001) [2] "Complete sequencing and charact

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF