Polycomb complex protein BMI-1 Polyclonal Antibody

Catalog Number:

42391

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P35226

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Polycomb complex protein BMI-1 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Polycomb complex protein BMI-1 polyclonal antibody.

Applications:

WB

Background:

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

References:

[1]Characterization and chromosomal localization of the human proto-oncogene BMI-1.Alkema M.J., Wiegand J., Raap A.K., Berns A., van Lohuizen M.Hum. Mol. Genet. 2:1597-1603(1993) [2]Complete sequencing and characterization of 21,243 full-length human c

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF