Heterogeneous nuclear ribonucleoprotein Q Polyclonal Antibody

Catalog Number:

42390

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O60506

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Heterogeneous nuclear ribonucleoprotein Q protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Heterogeneous nuclear ribonucleoprotein Q polyclonal antibody.

Applications:

WB IHC

Background:

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.

References:

[1] "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice."Harris C.E., Boden R.A., Astell C.R.J. Virol. 73:72-80(1999) [2] "Cloning of human and mouse GRY-RBP cDNA." Du G., Pan M., Zhou Y., Chen

appl_detail:

Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

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