Thioredoxin`Polyclonal Antibody

Catalog Number:

42377

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P10599

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Thioredoxin` protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Thioredoxin`polyclonal antibody.

Applications:

WB

Background:

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

References:

[1] "Nucleotide sequence of a cDNA encoding rat thioredoxin."Tonissen K.F., Robins A.J., Wells J.R.E. Nucleic Acids Res. 17:3973-3973(1989) [2] Xie Z.H., Liu C.Z., He Y.H., Wang A.M., Ma C. [3] "The status, quality, and expansion of the NIH full-leng

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF