Ubiquitin carboxyl-terminal hydrolase 14 Polyclonal Antibody

Catalog Number:

42364

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P54578

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Ubiquitin carboxyl-terminal hydrolase 14 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Ubiquitin carboxyl-terminal hydrolase 14 polyclonal antibody.

Applications:

WB

Background:

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).

References:

[1]tRNA-guanine transglycosylase cDNA from human placenta.Deshpande K.L., Katze J.R.Submitted (AUG-1995)[2]Cloning of human full-length CDSs in BD Creator(TM) system donor vector.Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundi

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF