Ganglioside GM2 activator Polyclonal Antibody

Catalog Number:

42346

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P17900

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Ganglioside GM2 activator protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Ganglioside GM2 activator polyclonal antibody.

Applications:

WB

Background:

Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.

References:

[1] "Isolation and expression of a full-length cDNA encoding the human G-M2 activator protein."Xie B., McInnes B., Neote K., Lamhonwah A.-M., Mahuran D.Biochem. Biophys. Res. Commun. 177:1217-1223(1991) [2] "Characterization of full-length cDNAs and th

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF