Mothers against decapentaplegic homolog 3 Polyclonal Antibody

Catalog Number:

42327

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P84022

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Mothers against decapentaplegic homolog 3 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Mothers against decapentaplegic homolog 3 polyclonal antibody.

Applications:

WB

Background:

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

References:

[1] "Receptor-associated Mad homologues synergize as effectors of the TGF-beta response."Zhang Y., Feng X.-H., Wu R.-Y., Derynck R.Nature 383:168-172(1996) [2] "Mad-related genes in the human."Riggins G.J., Thiagalingam S., Rose

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF