Histone H2B type 1-C/E/F/G/I Polyclonal Antibody

Catalog Number:

42283

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P62807

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Histone H2B type 1-C/E/F/G/I protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Histone H2B type 1-C/E/F/G/I polyclonal antibody.

Applications:

WB

Background:

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

References:

[1]"Isolation and characterization of two human H1 histone genes within clusters of core histone genes."Albig W., Kardalinou E., Drabent B., Zimmer A., Doenecke D.Genomics 10:940-948(1991) [2]"Human histone gene organization: nonregular arrangement withi

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF