Regulator of G-protein signaling 20 Polyclonal Antibody

Catalog Number:

42270

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O76081

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Regulator of G-protein signaling 20 protein£¨40-556aa£©

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Regulator of G-protein signaling 20 polyclonal antibody.

Applications:

IHC

Background:

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.

References:

[1]"Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling." Wang Y., Ho G., Zhang J.J., Nieuwenhuijsen B., Edris W., Chanda P.K., Young K.H. J. Biol. Chem. 277:48325-48332(2002). [2]"RG

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF