Rho guanine nucleotide exchange factor 7 Polyclonal Antibody

Catalog Number:

42257

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q14155

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant Human Rho guanine nucleotide exchange factor 7 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Rho guanine nucleotide exchange factor 7 polyclonal antibody.

Applications:

WB

Background:

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions By similarity. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

References:

[1] Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.DNA Res. 2:1

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF