DNA replication licensing factor MCM2 Polyclonal Antibody

Catalog Number:

42250

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P49736

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human DNA replication licensing factor MCM2 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total DNA replication licensing factor MCM2 polyclonal antibody.

Applications:

WB

Background:

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.

References:

[1]"A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division."Todorov I.T., Pepperkok R., Philipova R.N., Kearsey S.E., Ansorge W., Werner D.J. Cell Sci. 107:

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF