Glutamate carboxypeptidase 2 Polyclonal Antibody

Catalog Number:

42546

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q04609

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Glutamate carboxypeptidase 2 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Glutamate carboxypeptidase 2 polyclonal antibody.

Applications:

WB IHC

Background:

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

References:

[1]"Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen."IsraeliR.., Powell C.T., Fair W.R., Heston W.D.W.Cancer Res. 53:227-230(1993) [2]"Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio

appl_detail:

Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF