POU domain, class 5, transcription factor 1 Polyclonal Antibody

Catalog Number:

42543

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q01860

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human POU domain, class 5, transcription factor 1 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total POU domain, class 5, transcription factor 1 polyclonal antibody.

Applications:

WB

Background:

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.

References:

[1]"Phosphorylation regulates human OCT4."Brumbaugh J., Hou Z., Russell J.D., Howden S.E., Yu P., Ledvina A.R., Coon J.J., Thomson J.A.Proc. Natl. Acad. Sci. U.S.A. 109:7162-7168(2012). [2]"Serine 111 phosphorylation regulates OCT4A pro

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF