LRP6 Polyclonal Antibody

Catalog Number:

42243

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O75581

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Low-density lipoprotein receptor-related protein 6 protein (20-150aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total LRP6 polyclonal antibody.

Applications:

IHC

Background:

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

References:

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project Team Genome Res. 14:2121-2127(2004). [2]"Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6." Semenov M.V., Tamai K.,

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF