Indoleamine 2,3-dioxygenase 1 Polyclonal Antibody

Catalog Number:

42217

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P14902

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Indoleamine 2,3-dioxygenase 1 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Indoleamine 2,3-dioxygenase 1 polyclonal antibody.

Applications:

WB

Background:

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885).

References:

[1]Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA.Dai W., Gupta S.L. Biochem. Biophys. Res. Commun. 168:1-8(1990) [2]Primary structure of human indoleamine 2,3-dioxygenase deduced from

appl_detail:

Western blotting: 1:500 - 1:1000

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