Histone deacetylase 8 Polyclonal Antibody

Catalog Number:

42203

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9BY41

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Histone deacetylase 8 protein£¨1-377aa£©

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Histone deacetylase 8 polyclonal antibody.

Applications:

IHC

Background:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

References:

[1]"Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors." Dowling D.P., Gantt S.L., Gattis S.G., Fierke C.A., Christianson D.W.Biochemistry 47:13554-13563(2008) . [2]"Substrate binding t

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF