GDF5 Polyclonal Antibody

Catalog Number:

42177

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P43026

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Growth/differentiation factor 5 protein(202-501aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total GDF5 polyclonal antibody.

Applications:

IHC

Background:

Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

References:

[1]Mutations in GDF5 presenting as semidominant brachydactyly A1."Byrnes A.M., Racacho L., Nikkel S.M., Xiao F., MacDonald H., Underhill T.M., Bulman D.E. Hum. Mutat. 31:1155-1162(2010). [2]Novel point mutations in GDF5 associated with two distinct limb m

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF