Transforming protein RhoA Polyclonal Antibody

Catalog Number:

42171

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P61586

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Transforming protein RhoA protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Transforming protein RhoA polyclonal antibody.

Applications:

IHC

Background:

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex.

References:

[1]"Nucleotide sequence of human rho cDNA clone 12."Yeramian P., Chardin P., Madaule P., Tavitian A.Nucleic Acids Res. 15:1869-1869(1987) [2]"Sequence of rho small GTP-binding protein cDNAs from human retina and identification of novel 5' end cloning art

appl_detail:

Immunohistochemistry: 1:20 - 1:200

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