Cyclic AMP-responsive element-binding protein 1 Polyclonal Antibody

Catalog Number:

42135

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P16220

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Cyclic AMP-responsive element-binding protein 1 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Cyclic AMP-responsive element-binding protein 1 polyclonal antibody.

Applications:

WB

Background:

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

References:

[1] "Two distinct forms of active transcription factor CREB (cAMP response element binding protein)."Berkowitz L.A., Gilman M.Z.Proc. Natl. Acad. Sci. U.S.A. 87:5258-5262(1990) [2] "Multiple cDNA clones encoding nuclear proteins that bind to the tax-dep

appl_detail:

Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF