Complement C5a anaphylatoxin Polyclonal Antibody

Catalog Number:

42092

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P01032

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant Pig Complement C5a anaphylatoxin protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Complement C5a anaphylatoxin polyclonal antibody.

Applications:

IHC

Background:

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).

References:

[1]Amino acid sequence of the anaphylatoxin from the fifth component of porcine complement.Gerard C., Hugli T.E.J. Biol. Chem. 255:4710-4715(1980) [2]Identification of classical anaphylatoxin as the des-Arg form of the C5a molecule: evidence of a modul

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF