Eukaryotic initiation factor 4A-II Polyclonal Antibody

Catalog Number:

42091

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q14240

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Eukaryotic initiation factor 4A-II protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Eukaryotic initiation factor 4A-II polyclonal antibody.

Applications:

WB

Background:

Eukaryotic initiation factor 4A plays an important role in the binding of mRNA to the 43S preinitiation complex when protein synthesis begins. Two highly homologous forms of functional EIF4A genes, Eif4a1 and Eif4a2, have been isolated in mice; yeast cells also possess 2 EIF4A genes, TIF1 and TIF2. The murine Eif4a and yeast TIF genes appear to belong to a DEAD-box gene family, whose members exhibit extensive amino acid similarity and contain the asp-glu-ala-asp (DEAD) sequence. DEAD-box genes have been identified in species ranging from E-coli to humans. Their function appears to be related to transcriptional/translational regulation (referenced from OMIM).

References:

[1] "Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2."Sudo K., Takahashi E., Nakamura Y.Cytogenet. Cell Genet. 71:385-388(1995) [2] "Cloning of human full-length CDSs in BD Cr

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF