AZU1 Polyclonal Antibody

Catalog Number:

42077

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P20160

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Azurocidin protein (27-251aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total AZU1 polyclonal antibody.

Applications:

WB IHC

Background:

This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.

References:

[1]Atomic resolution structure of human HBP/CAP37/azurocidin."Karlsen S., Iversen L.F., Larsen I.K., Flodgaard H.J., Kastrup J.S.Acta Crystallogr. D 54:598-609(1998). [2]Structure of HBP, a multifunctional protein with a serine proteinase fold."Iversen L.

appl_detail:

Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF