Granzyme B Polyclonal Antibody

Catalog Number:	42196
other_names:	C11, CTLA-1, Cathepsin G-like 1, CTSGL1, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, Fragmentin-2, Granzyme-2, Human lymphocyte protein, HLP, SECT, T-cell serine protease 1-3E, GZMB, CGL1, CSPB, CTLA1, GRB
Amount:	100μg
calculated_mw:	28kd
host_species:	Rabbit
Price:	$319
Swiss-Prot No:	Swiss-Prot#: P10144
Form of Antibody:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage/Stability:
Immunogen:	Recombinant human Granzyme B protein
Purification:	Caprylic Acid Ammonium Sulfate Precipitation purified
Specificity/Sensitivity:	The antibody detects endogenous level of total Granzyme B polyclonal antibody.
Applications:	WB
Background:	This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
References:	[1]"Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."Saito S., Iida A., Sekine A., Kawauchi S., Higuchi S., Ogawa C., Nakamura Y.J. Hum. Genet. 48:249-270
appl_detail:	Western blotting: 1:500 - 1:1000
	Datasheet PDF

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