GZMA Polyclonal Antibody

Catalog Number:

42195

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P12544

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Granzyme A protein (29-262aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total GZMA polyclonal antibody.

Applications:

IHC

Background:

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.

References:

[1]"Crystal structure of the apoptosis-inducing human granzyme A dimer."Hink-Schauer C., Estebanez-Perpina E., Kurschus F.C., Bode W., Jenne D.E.Nat. Struct. Biol. 10:535-540(2003). [2]"The oligomeric structure of human granzyme A is a determinant of its

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF