U1 small nuclear ribonucleoprotein A Polyclonal Antibody

Catalog Number:

42190

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P09012

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human U1 small nuclear ribonucleoprotein A protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total U1 small nuclear ribonucleoprotein A polyclonal antibody.

Applications:

IHC

Background:

Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process.

References:

[1]"Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein."Nelissen R.L.H., Sillekens P.T.G., Beijer R.P., Geurts van Kessel A.H.M., van Venrooij W.J.Gene 102:189-196(1991)[2

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF