RUNX1T1 Antibody

Catalog Number:

37883

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q06455
NCBI Gene ID: 862
Gene Accssion: NP_001185554/Q06455

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RUNX1T1 protein.

Applications:

IHC

Background:

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.?

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF