RNF139 Antibody

Catalog Number:

37873

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8WU17
NCBI Gene ID: 11236
Gene Accssion: NP_009149/Q8WU17

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human ring finger protein 139

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RNF139 protein.

Applications:

IHC

Background:

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF