MARVELD1 Antibody

Catalog Number:

37717

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9BSK0
NCBI Gene ID: 83742
Gene Accssion: NP_113672

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human MARVEL domain containing 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MARVELD1 protein.

Applications:

WB IHC

Background:

MARVELD1 (MARVEL domain containing 1), also known as GB14, MARVD1 or MRVLDC1, is a 173 amino acid protein that is widely expressed and contains one MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain. The MARVEL domain, which is common in Occludin proteins, is a 130 amino acid motif that contains four transmembrane helices, both of which have cytoplasmic N- and C-terminal regions. Localizing to the nucleus, MARVELD1 is downregulated in primary multiple tumors of liver, bladder, ovary, vulva, breast, testis, uterus, kidney and testis. The gene encoding MARVELD1 maps to human chromosome 10, which makes up approximately 4.5% of total DNA in cells and encodes nearly 1,200 genes. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman¡¯s syndrome and Cowden syndrome.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200

Datasheet PDF