MAGEL2 Antibody

Catalog Number:

37712

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UJ55
NCBI Gene ID: 54551
Gene Accssion: NP_061939

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human MAGE-like 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MAGEL2 protein.

Applications:

WB

Background:

Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.

References:

appl_detail:

Western blotting: 1:200-1:1000

Datasheet PDF