CERS6 Antibody

Catalog Number:

37698

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q6ZMG9
NCBI Gene ID: 253782
Gene Accssion: NP_982288

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human ceramide synthase 6

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CERS6 protein.

Applications:

IHC

Background:

The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they all are involved in sphingolipid synthesis. LASS6 is a widely expressed 384 amino acid endoplasmic reticulum, multi-pass membrane protein. On the luminal side of the endoplasmic reticulum membrane, the N-terminal asparagine residue is glycosylated. In cells deficient for CLN9, LASS6 corrects growth and apoptosis, and increases the levels of short ceramide species, such as C14:0- and C16:0-ceramides.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF