HACE1 Antibody

Catalog Number:

37612

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8IYU2
NCBI Gene ID: 57531
Gene Accssion: NP_065822

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HACE1 protein.

Applications:

IHC

Background:

HACE1 (HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1), also known as KIAA1320, is a 909 amino acid protein that localizes to both the cytoplasm and the endoplasmic reticulum and contains one HECT domain and six ANK repeats. Expressed in kidney, heart and brain, HACE1 functions as an E3 ubiquitin-protein ligase that interacts with the proteasome and is thought to play a role in protein degradation. HACE1 is downregulated in Wilms tumor, suggesting a possible role in tumor suppression.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF